The Maple Trial
MAPLE is a clinical trial which is being undertaken to learn more about potential treatments for Autosomal Dominant Polycystic Kidney Disease (ADPKD).
This study will test a new possible drug that could be used in the future for patients with ADPKD. The goal of this medication, if it works, is to slow down the growth of cysts in the kidneys to help the kidneys work better for a longer time. It won’t cure ADPKD.
You may be able to join the MAPLE study if you:
- are between the ages of 25 and 65
- have a diagnosis of ADPKD
- have an eGFR or greater or equal to 45 mL/min/1.73m2
- are comfortable having an MRI scan of your abdomen to measure the size of your kidneys
- aren’t receiving or taking Tolvaptan
- haven’t received a transplant
- do not have type 1 or type 2 diabetes or a history of thyroid problems
If you are a woman:
- you cannot be pregnant or breastfeeding
- if you are able to have children, you must agree to use contraception that will be discussed with by the study staff
- you must have a negative pregnancy test.
What happens during the study?
Participants start their journey with a screening visit where the study doctor will tell you about the study. If you agree, you will have some blood tests and routine tests such as Physical Examination, ECG and vital signs to see if you meet the eligibility criteria. You will also have an MRI scan.
Then, if you are able to participate, the study doctor will schedule an appointment for you to come to the clinic for a few hours and receive one dose of the study medication by a small injection into the fat just below your skin (known as a subcutaneous injection).
You will come back to the clinic 10 more times for approximately 2hrs each time over the next 6 months. Depending on the visit you will have blood tests and other routine tests to monitor your health.
Interested in joining?
If you are interested in finding out more about the study please contact the most appropriate site for you:
Royal Free London Hospital
- Renal Research Team: 020 7472 6491
- Email: [email protected]
Royal Devon and Exeter Hospital
- Phone number: 01392 406979
- Email: [email protected]
GSK Clinical Unit Cambridge
- Phone number: 01223 296001 (Please ask reception to redirect you to the recruitment coordinator- Sandra Hook)
- Email: [email protected]
If you’d like to learn more about PKD research studies, please contact the PKD Charity PPIE Officer: [email protected].